. Author manuscript; available in PMC: 2019 Aug 1.

Published in final edited form as: Vasc Med. 2018 May 8;23(4):340–348. doi: 10.1177/1358863X18765667

Table 4.

Correlations of MtDNA copy number with markers of mitochondrial activity and mitochondrial biogenesis among participants with PAD.^a

	All PAD participants (n=34)^a	ABI < 0.60 (n=l2)	ABI 0.60–0.90 (n=2l)
Relative COX activity
Pearson correlation coefficient with mitochondrial DNA copy number	0.385	0.478	0.3l6
p-value	p=0.033	p=0.ll6	p=0.202
Relative citrate synthase activity
Pearson correlation coefficient with mitochondrial DNA copy number	0.038	−0.25l	0.479
p-value	p=0.835	p=0.432	p=0.038
Log-transformed PGC-1α
Pearson correlation coefficient with mitochondrial DNA copy number	0.253	0.03l	0.453
p-value	p=0.l69	p=0.924	p=0.059
Maximum relative brachial artery FMD 60/90 (%)
Pearson correlation coefficient with mitochondrial DNA copy number	0.255	−0.043	0.465
p-value	p=0.l66	p=0.90l	p=0.039

ABI, ankle–brachial index; FMD, flow-mediated dilation; MtDNA, mitochondrial DNA; PAD, peripheral artery disease.

One participant with documented PAD and a history of revascularization had an ABI > 0.90.