Table S1:

OARSI scoring system.

Grade	Osteoarthritic damage
0	Normal
0.5	Loss of safranin-O without structural changes
1	Small fibrillations without loss of cartilage
2	Vertical clefts down to the layer immediately below the superficial layer and some loss of surface lamina
3	Vertical clefts/erosion to the calcified cartilage extending to <25% of the articular surface
4	Vertical clefts/erosion to the calcified cartilage extending to 25–50% of the articular surface
5	Vertical clefts/erosion to the calcified cartilage extending to 50–75% of the articular surface
6	Vertical clefts/erosion to the calcified cartilage extending >75% of the articular surface