Table 2.

Demographics of Zimmerman program VWD subjects

VWD type	Type 1 VWD	Historical type 1 VWD	Type 2	Type 3
Median age at enrollment (in years, ±1 SD)	15±16	16±16	18±20	21±17
Gender (% M:% F)	34:66	33:67	46:54	47:53
Median VWF:Ag (in IU/dL, ±1 SD)	36±17	76±45	32±32	N/A*
Median VWF:RCo (in IU/dL, ±1 SD)	33±16	72±40	24±25	N/A*
Median bleeding score (ISTH**, ±1 SD)	5±5	5±6	9±6	15±8

^*, Unless the subject had received treatment at time of study enrollment, VWF:Ag <1 lU/dL and VWF:RCo <10 lU/dL;

^**, bleeding scores were calculated according to the ISTH Bleeding Assessment Tool (11). VWD, von Willebrand disease; SD, standard deviation; M, male; F, female; VWF:Ag, von Willebrand factor antigen; VWF:RCo, von Willebrand factor ristocetin cofactor activity assay; ISTH, International Society on Thrombosis and Haemostasis.