REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit polyclonal antibody anti-TRPA1	Novus	Cat# NB110-40763; RRID: AB_715124
Rabbit polyclonal antibody anti-TRPA1	Sigma-Aldrich	Cat# HPA026630; RRID: AB_1858360
Rabbit polyclonal antibody anti-Cleaved Caspase-3 (Asp175)	Cell Signaling Technology	Cat# 9661; RRID: AB_2341188
Mouse monoclonal antibody anti-Ki-67	Dako	Cat# M7240; RRID: AB_2142367
Mouse monoclonal anti-Flag M2 antibody	Sigma-Aldrich	Cat# F1804; RRID: AB_259529
Mouse monoclonal antibody anti-beta-Actin	Sigma-Aldrich	Cat# A1978; RRID: AB_476692
Rabbit polyclonal antibody anti-Phospho-4E-BP1 (Ser65)	Cell Signaling Technology	Cat# 9451; RRID: AB_330947
Rabbit monoclonal antibody anti-4E-BP1	Cell Signaling Technology	Cat# 9644S; RRID: AB_10691384
Mouse monoclonal antibody anti-Phospho-S6 Ribosomal Protein (Ser240)	Dako	Cat# M7300; RRID: AB_2182542
Rabbit monoclonal antibody anti-S6 Ribosomal Protein	Cell Signaling Technology	Cat# 2217; RRID: AB_331355
Rabbit monoclonal antibody anti-Phospho-AKT (Thr308)	Cell Signaling Technology	Cat# 4056; RRID: AB_331163
Mouse monoclonal antibody anti-AKT	Cell Signaling Technology	Cat# 2920; RRID: AB_1147620
Rabbit monoclonal antibody anti-Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)	Cell Signaling Technology	Cat# 4370; RRID: AB_2315112
Rabbit polyclonal antibody anti-p44/42 MAPK (Erk1/2)	Cell Signaling Technology	Cat# 9102; RRID: AB_330744
Rabbit polyclonal antibody anti-Phospho-PYK2 (Tyr402)	Cell Signaling Technology	Cat# 3291S; RRID: AB_2300530
Mouse monoclonal antibody anti-PYK2	Cell Signaling Technology	Cat# 3480S; RRID: AB_2174093
Rabbit monoclonal antibody anti-MCL-1	Cell Signaling Technology	Cat# 5453S; RRID: AB_10694494
Rabbit polyclonal antibody anti-Phospho-SRC (Tyr416)	Cell Signaling Technology	Cat# 2101; RRID: AB_331697
Rabbit polyclonal antibody anti-SRC	Cell Signaling Technology	Cat# 2108; RRID: AB_331137
Mouse monoclonal antibody anti-Methylglyoxal	Cell Biolabs, Inc	Cat# STA-011
Rabbit polyclonal antibody anti-4 Hydroxynonenal	Abcam	Cat# ab46545; RRID: AB_722490
Mouse monoclonal antibody anti-8 Hydroxyguanosine	Abcam	Cat# ab48508; RRID: AB_867461
Biological Samples
Unstained breast cancer tissue arrays	US Biomax	BR1504a
Unstained normal breast tissue arrays	US Biomax	BN08111
Unstained lung cancer tissue arrays	US Biomax	BC041115d
Unstained normal lung tissue arrays	US Biomax	LCN241
Chemicals, Peptides, and Recombinant Proteins
AP-18	Sigma-Aldrich	Cat# A7232, CAS: 55224-94-7
AM-0902	Schenkel et al., 2016	N/A
Fura-2	Thermo Fisher Scientific	Cat# F1201
N-Acetyl-L-cysteine	Sigma-Aldrich	Cat# A7250, CAS: 616-91-1
Hydrogen peroxide solution	Sigma-Aldrich	Cat# H1009, CAS: 7722-84-1
Allyl isothiocyanate (Mustard oil)	Sigma-Aldrich	Cat# W203408, CAS: 57-06-7
BAPTA, AM, cell permeant chelator	Thermo Fisher Scientific	Cat# B1205
Peroxy green 1	Miller et al., 2007	N/A
Carboplatin	Sigma-Aldrich	Cat# C2538, CAS: 41575-94-4
Gemcitabine hydrochloride	Sigma-Aldrich	Cat# G6423, CAS: 122111-03-9
Doxorubicin hydrochloride	Sigma-Aldrich	Cat# 44583, CAS: 25316-40-9
Paclitaxel	Sigma-Aldrich	Cat# T7402, CAS: 33069-62-4
CellEvent™ Caspase-3/7 Green Detection Reagent	Thermo Fisher Scientific	Cat# C10423
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride (W-7)	Sigma-Aldrich	Cat# A3281 CAS: 61714-27-0
Trifluoperazine dihydrochloride (TFP)	Sigma-Aldrich	Cat# T8516 CAS: 440-17-5
PD325901	Selleckchem	Cat# S1036
Torin1	Tocris	Cat# 4247
KN-93	Santa Cruz Biotechnology	Cat# sc-202199 CAS: 139298-40-1
A-1210477	Selleckchem	Cat# S7790
Critical Commercial Assays
Active Ras Pull-Down and Detection Kit	Thermo Fisher Scientific	Cat# 16117
Mem-PER™ Plus Membrane Protein Extraction Kit	Thermo Fisher Scientific	Cat# 89842
Fluo-4 NW Calcium Assay Kit	Thermo Fisher Scientific	Cat# F36206
Trichrome Stain	Abcam	Cat# ab150686
GSH/GSSG-Glo™ Assay	PROMEGA	Cat# V6611
Deposited Data
RNA-seq, gene alteration, paired clinical feature, and RPPA data for tumors and corresponding normal tissues	TCGA	https://gdac.broadinstitute.org or http://www.cbioportal.org
Normalized gene expression data and paired clinical feature data including survival	METABRIC	European Genome-phenome Archive: EGAD00010000210, EGAD0001000021
Expression dataset for MPNST	Miller et al., 2009	GEO: GSE14038
RNA-seq data for HCI PDX models	This paper	GEO: GSE113476
Experimental Models: Cell Lines
MCF-10A	Laboratory of Dennis Slamon	N/A
HCC1569	Laboratory of Dennis Slamon	N/A
HCC38	Laboratory of Dennis Slamon	N/A
HCC202	Laboratory of Dennis Slamon	N/A
HCC70	Laboratory of Dennis Slamon	N/A
HCC1500	Laboratory of Dennis Slamon	N/A
MDAMB-175	Laboratory of Dennis Slamon	N/A
T47D	Laboratory of Dennis Slamon	N/A
BT-549	Laboratory of Dennis Slamon	N/A
H1792	ATCC	Cat# CRL-5895; RRID: CVCL_1495
H647	ATCC	Cat# CRL-5834; RRID: CVCL_1574
A549	ATCC	Cat# CCL-185; RRID: CVCL_0023
H358	ATCC	Cat# CRL-5807; RRID: CVCL_1559
H23	ATCC	Cat# CRL-5800; RRID: CVCL_1547
sNF96.2	ATCC	Cat# CRL-2884; RRID: CVCL_K281
90-8TL	Laboratory of Eric Legius	N/A
88-14	Laboratory of Jonathan Fletcher	N/A
S462	Laboratory of Eric Legius	N/A
EL-12-58	Johnson et al., 2016	N/A
HCI-002	This paper	N/A
Experimental Models: Organisms/Strains
Mouse: NOD-Rag1null Il22rgnull (NRG)	Jackson Laboratory	Stock#: 007799
Oligonucleotides
Primers for the construction of TRPA1 mutants: listed in Table S2	This paper	N/A
Primers for the construction of LentiCRISPR plasmids: listed in Table S4	This paper	N/A
Primers for quantitative PCR: listed in Table S5	This paper	N/A
Recombinant DNA
pENTR223.1-TRPA1	GE Healthcare	Cat# OHS5893-202502591
pC1-HyPer-2	Addgene	Cat# 42211
pC1-HyPer-C199S	Addgene	Cat# 42213
pLX304	Addgene	Cat# 25890
pCDH (Puromycin resistance)	System Bioscience	Cat# CD510B-1
pCDH (Hygromycin B resistance)	System Bioscience	Cat# CD515B-1
pCI-neo-TRPA1	Takahashi et al., 2011	N/A
pCI-neo-TRPA1 mutant	This paper	N/A
pCDNA3.1-Flag-NRF2	Addgene	Cat# 36971
LentiCRISPR plasmids	This paper	N/A
pLX304-TRPA1	This paper	N/A
pLX304-MCL-1	GE Healthcare	Cat# OHS6085-213573654
pCDH-Hyper-2 (Puro and Hygromycin B)	This paper	N/A
pCDH-HyPer-C199S (Puro and Hygromycin B)	This paper	N/A
shRNA: TRPA1 #1	The RNAi Consortium	TRCN0000044801
shRNA: TRPA1 #2	The RNAi Consortium	TRCN0000434290
shRNA: GFP	Addgene	30323
Inducible shRNA: NFE2L2 #1	GE Healthcare	V3THS_306092
Inducible shRNA: NFE2L2 #2	GE Healthcare	V3THS_306096
Inducible shRNA: non-silencing control	GE Healthcare	RHS4743
SMARTpool siRNA for PYK2	GE Healthcare	L-003165-00
SMARTpool siRNA for NFE2L2	GE Healthcare	L-003755-00
SMARTpool siRNA for TRPM2	GE Healthcare	L-004193-00
siGENOME Non-Targeting siRNA Pool #2	GE Healthcare	D-001206-14
Software and Algorithms
GraphPad Prism 7.0	GraphPad Prism Software	N/A
Cluster 3.0	N/A	http://bonsai.hgc.jp/~mdehoon/software/cluster/software.htm
Java TreeView	N/A	http://jtreeview.sourceforge.net/
Metafluor	Molecular Devices	N/A
Other
RPPA assay	RPPA Core Facility - MD Anderson Cancer Center	N/A