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. 2018 Aug 15;10:2729–2742. doi: 10.2147/CMAR.S167846

Figure 5.

Figure 5

Eribulin inhibits growth and EMT of MKN-45 cell/HPMC coculture-derived subcutaneous fibrotic xenograft tumors and demonstrates synergism with 5-FU.

Notes: (A) Volumes of tumors derived from MKN-45 cell/HPMC cocultures in mice treated with eribulin and/or 5-FU. Each tumor volume was measured every fourth day (n=5). (B) Body weights of mice carrying tumor xenografts, expressed in relation to preinoculation weights. (C) H&E and azan staining, fluorescent labeling, and immunohistochemical staining of subcutaneous xenograft tumors 28 days after inoculation (original magnification of 200×). (D) The fibrotic area was measured and shown as percentage (fibrotic area/whole section area) of azan staining in (C). Data are expressed as means ± SD. ##p<0.01, #p<0.05, ns: not significant.

Abbreviations: EMT, epithelial–mesenchymal transition; 5-FU, 5-fluorouracil; H&E, hematoxylin and eosin; HPMCs, human peritoneal mesothelial cells; TGF-β, transforming growth factor-β.