Table 1. HCI-2509 and SAHA inhibitory concentrations.
| HCI-2509 (iLSD1) | SAHA | |||||
|---|---|---|---|---|---|---|
| Cell Line | Fusion type | 1q Copy number | IC50 (µM) | s.d. | IC50 (µM) | s.d. |
| A4573 | EWS-FLI1 | Gain | 0.247 | 0.025 | 0.673 | 0.086 |
| A673 | EWS-FLI1 | Normal | 0.097 | 0.053 | 1.676 | 0.347 |
| CADO-ES | EWS-ERG | Gain | 0.282 | 0.039 | 1.089 | 0.169 |
| RDES | EWS-FLI1 | Gain | 0.485 | 0.095 | 0.867 | 0.145 |
| RM82 | EWS-ERG | Gain | 0.534 | 0.079 | 1.261 | 0.135 |
| SKNMC | EWS-FLI1 | Normal | 0.226 | 0.008 | 0.946 | 0.074 |
| SK-ES-1 | EWS-FLI1 | Gain | 0.351 | 0.010 | 1.262 | 0.140 |
| STA-ET10 | EWS-FEV | Gain | 0.315 | 0.009 | 0.712 | 0.071 |
| TC32 | EWS-FLI1 | Gain | 0.187 | 0.019 | 1.553 | 0.161 |
| TC71 | EWS-FLI1 | Gain | 0.252 | 0.018 | 1.254 | 0.137 |
| TTC466 | EWS-ERG | Normal | 0.251 | 0.013 | 0.765 | 0.148 |
| WE68 | EWS-FLI1 | Gain | 0.317 | 0.010 | 0.974 | 0.039 |
Proliferation IC50 of 12 ES cell lines assayed for HCI-2509 or SAHA sensitivity and measured after 72 h exposition to the drugs (n = 4).