Table 1. HCI-2509 and SAHA inhibitory concentrations.
HCI-2509 (iLSD1) | SAHA | |||||
---|---|---|---|---|---|---|
Cell Line | Fusion type | 1q Copy number | IC50 (µM) | s.d. | IC50 (µM) | s.d. |
A4573 | EWS-FLI1 | Gain | 0.247 | 0.025 | 0.673 | 0.086 |
A673 | EWS-FLI1 | Normal | 0.097 | 0.053 | 1.676 | 0.347 |
CADO-ES | EWS-ERG | Gain | 0.282 | 0.039 | 1.089 | 0.169 |
RDES | EWS-FLI1 | Gain | 0.485 | 0.095 | 0.867 | 0.145 |
RM82 | EWS-ERG | Gain | 0.534 | 0.079 | 1.261 | 0.135 |
SKNMC | EWS-FLI1 | Normal | 0.226 | 0.008 | 0.946 | 0.074 |
SK-ES-1 | EWS-FLI1 | Gain | 0.351 | 0.010 | 1.262 | 0.140 |
STA-ET10 | EWS-FEV | Gain | 0.315 | 0.009 | 0.712 | 0.071 |
TC32 | EWS-FLI1 | Gain | 0.187 | 0.019 | 1.553 | 0.161 |
TC71 | EWS-FLI1 | Gain | 0.252 | 0.018 | 1.254 | 0.137 |
TTC466 | EWS-ERG | Normal | 0.251 | 0.013 | 0.765 | 0.148 |
WE68 | EWS-FLI1 | Gain | 0.317 | 0.010 | 0.974 | 0.039 |
Proliferation IC50 of 12 ES cell lines assayed for HCI-2509 or SAHA sensitivity and measured after 72 h exposition to the drugs (n = 4).