Fig 5. Supervised clustering of genes implicated in pathways of importance in human iUC.

Genes reported to be of importance in p53 (A), p63 (B) and PPARG (C) pathways in human iUC were assessed in the canine iUC transcriptional subtypes. Normalized intensity values were used for supervised hierarchical clustering using Euclidean distance metrics and Ward’s linkage algorithm as a distance metric. Supervised clustering of the data reveals similar patterns of these genes as reported in human iUC.