Figure 3.
Differences and similarities of differential methylation across the whole genome in ageing and cancer in different tissues. (A) Overlap of genes that are differentially methylated in their TSS1500 region in ageing (green) and cancer (purple). P-value indicates significance of the overlap when compared to the overlap between 1000 random gene selections of the same size. (B) Within tissue correlations of slopes output from the probe-level linear regression models of ageing and cancer. All correlations are significant excluding LIHC (Pearson correlation; P-value: 0.34). (C) Inter-tissue correlations of slopes output by the linear regression model of ageing. All correlations are significant (P-values < 10−5; Pearson correlation). (D) Inter-tissue correlations of slopes output by the linear regression model of cancer. All correlations are significant (P-values = 0; Pearson correlation).