Table 3.
Summary of the Findings Involving Hippocampal Neurogenesis in Rodent Models of Cacna1c/Cav1.2 Dysfunction
| Model | Proliferation Rate | Immature Neurons | Cell Survival | Dentate Gyrus Size | |
|---|---|---|---|---|---|
| Lee et al51 | Forebrain-Cav1.2 CkO (−/−) | n.d. | ↓ | ↓ | n.d. |
| Temme et al50 | Neuron-specific deletion of Cav1.2 CkO (−/−) | ↓ | ↓ | n.d. | |
| Völkening et al68 | TgGLAST-CreERT2 /Cacna1cfl/fl /RCE:loxP mice (Mouse model with Cacna1c-deficient Type-1 cells) | ↓ | ↓ | ||
| Moon et al, this study | Cacna1c+/− rat model | ↓ | n.d. | n.d. |
Note: n.d., no significant difference seen.