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. Author manuscript; available in PMC: 2019 Jul 4.
Published in final edited form as: Adv Funct Mater. 2017 Sep 4;28(27):1702570. doi: 10.1002/adfm.201702570

Figure 6.

Figure 6

Runx2 transcription factor and osteogenesis markers induced in cells seeded on silk-silica films, while the use of a blocking antibody against integrin αVβ3 abolished the induction. Gene expression of Runx2 transcription factor (A), and bone extracellular matrix proteins Bone Sialoprotein (BSP) (B), osteocalcin (OC) (C) and Matrix Metalloproteinase-2 (MMP-2) (D), was monitored from cells growing on tissue culture plastic (TCP; white bars), 15mer-ch (light gray bars), 15mer-ch in the presence of blocking antibody (15mer-ch anti-αV; dark gray bars), R5-15mer-ch (light black bars), and R5 chimera films in the presence of blocking antibody (R5-15mer-ch anti-αV; black bars) silicified films. Data represents mean ± SD (n=3) *: p<0.05; **: p <0.01; ***: p <0.001.