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. Author manuscript; available in PMC: 2019 Jul 4.
Published in final edited form as: Adv Funct Mater. 2017 Sep 4;28(27):1702570. doi: 10.1002/adfm.201702570

Figure 7.

Figure 7

The three MAPK pathways and c-Jun were induced and activated in cells seeded on silk-silica films. The treatment with a neutralizing αVβ3 antibody abrogates the induction. Gene expression of MAPK ERK2 (A), p38 (B), JNK2 (C) and c-Jun (D), was monitored from cells growing on tissue culture plastic (TCP; white bars), 15mer-ch (light gray bars), 15mer-ch in the presence of blocking antibody (15mer-ch anti-αV; dark gray bars), R5-15mer-ch (light black bars), and R5 chimera films in the presence of blocking antibody (R5-15mer-ch anti-αV; black bars) silicified films. E) Immunoblotting analysis of ERK, and JNK proteins, and its phosphorylated versions P-ERK and P-JNK proteins. GAPDH is used as load control. Data represents mean ± SD (n=3) *: p<0.05; **: p <0.01; ***: p <0.001.