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. 2018 Aug 7;7:e35738. doi: 10.7554/eLife.35738

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© 2018, Kane et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 4. — (A) Schematic representation of the nuclear pore complex and genes included in siRNA library color coded by subcomplex. (*NUP98 is listed as a member of Nup107 subcomplex, however. NUP98 and NUP96 are produced following autoproteolytic cleavage of a polyprotein precursor (Fontoura et al., 1999; Rosenblum and Blobel, 1999), the siRNA used herein targets both Nups). Importins/nuclear transport receptors (NTRs) included in the siRNA library are listed in black. Also included, siRNA targeting MX2 or CPSF6 and a non-targeting control siRNA. (B) Experimental strategy to investigate the roles of Nups and NTRs involved in HIV-1 infection, MX2 subcellular localization, and anti-viral activity of MX2. For a detailed description, refer to the Materials and methods.