Table 4.

Relations of microscopic synovitis and synovium gene expression with articular cartilage glycosaminoglycan loss in post-surgery animals (Transcripts with p < 0.05 and FDR ≤ 0.20).

Gene symbol	Description	Slope *	R̂2	p	FDR
	Synovial cell count	-	0.31	5.23E-04
	Synovial tissue area	+	0.09	.103
ITGA8	Integrin alpha-8	-	0.44	1.51E-05	0.02
GATM	Glycine amidinotransferase, mitochondrial	-	0.40	5.11E-05	0.04
U6	-	-	0.37	1.27E-04	0.06
FGF7	Fibroblast growth factor 7	-	0.32	4.87E-04	0.12
ARHGAP28	Rho GTPase-activating protein 28	-	0.32	4.99E-04	0.12
VMP1	Vacuole membrane protein 1	-	0.31	5.69E-04	0.12
RUNX2	Runt-related transcription factor 2	-	0.30	6.85E-04	0.12
ENSSSCG00000020975 **	Novel protein coding	-	0.30	7.26E-04	0.12
EYA3 ***	Eyes absent homolog 3	-	0.30	7.75E-04	0.12
PCOLCE	Procollagen C-endopeptidase enhancer 1	+	0.28	1.12E-03	0.16
ATRAID	All-trans retinoic acid-induced differentiation factor	+	0.27	1.44E-03	0.17
ssc-mir-21	-	-	0.27	1.49E-03	0.17
TFPI	Tissue factor pathway inhibitor	-	0.27	1.64E-03	0.17
PLXDC1	Plexin domain-containing protein 1	+	0.27	1.74E-03	0.17
PCDH17	Protocadherin-17	-	0.26	2.14E-03	0.20
R3HDM1	R3H domain-containing protein 1	-	0.25	2.30E-03	0.20
EFR3A	Protein EFR3 homolog A	-	0.25	2.74E-03	0.20
SHOX2	Short stature homeobox protein 2	+	0.25	2.82E-03	0.20
LEF1	Lymphoid enhancer-binding factor 1	-	0.24	2.88E-03	0.20
KIAA1217	Sickle tail protein homolog	-	0.24	2.91E-03	0.20

^*A negative slope (-) indicates that higher expression levels are associated with lower Safranin-O saturation values (i.e. GAG loss), a positive slope (+) indicates that higher expression levels are associated with higher Safranin-O saturation values;

^**gene symbol not available;

^***orthologue