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. 2018 Jun 15;293(33):12934–12944. doi: 10.1074/jbc.RA117.001267

Figure 2.

Figure 2.

B cell development defect in Hrd1 KO mice is independent of ER stress-associated proteins IRE1α and CHOP. A, qPCR of B220+ BM cells measuring ER stress-associated genes Xbp1, Chop, Bip, and Erdj3. B, bone marrow from WT, Hrd1 KO, Ire1α KO, and double KO (DKO) littermates were analyzed for B220LOIgM+ pro–B and pre–B cells, B220LOIgM+ immature B cells, and B220HIIgM+ mature B cells. The percentages (C) and total number (D) of B cell development stages as analyzed in B are shown. E, WT, Hrd1 KO, Chop KO, and DKO littermates were analyzed for B cell development as in B. The percentages (F) and total number (G) of B cell development stages as measured in E are shown. Error bars represent S.D. n = 5. *, p < 0.05; **, p < 0.01; ***, p < 0.001.