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. 2018 Jun 22;293(33):12663–12680. doi: 10.1074/jbc.RA117.000871

Table 2.

Inhibition (Ki) of APPIWT and APPI-4M toward various human serine proteases

KLK6 Anionic trypsin Cationic trypsin FXIa
pm pm pm pm
APPIWT (2240 ± 110) (1.74 ± 0.05) (6.27 ± 1.01) (410 ± 14)
APPI-4M (160 ± 60) (69.8 ± 8.0) (168 ± 17.5) (724.8 ± 33.7)
Fold difference 14 0.025 0.037 0.58