. 2018 Apr 9;8(4):303–319. doi: 10.1007/s13659-018-0162-1

Table 3.

Anti-lung cancer cells activities of artemisinins

Compounds	Effect	Event/mechanism	References
AS	Enhanced radiosensitivity Induced cell cycle arrest	Increased the NO levels, down-regulated cyclin B1 mRNA expression	[42]
AS	Inhibited invasion Inhibited metastasis	Inhibited urokinase-type plasminogen activator (u-PA) activity, -protein and -mRNA expression, down-regulated MMP-2-, MMP-7- and u-PA-promoter/-enhancer activity, suppressed AP-1- and NF-κB-transactivation	[87]
AS	Influenced ribosomal activity, drug transport, cellular antioxidant defense Induced apoptosis Inhibited proliferation Arrested cell cycle	Related to tumor necrosis factor (TNF) and the tumor suppressor p53, influenced the activity of transcription factors regulating downstream genes, influenced by c-Myc and Max-mediated transcriptional control of gene expression	[88]
ART, DHA, AS	Inhibit proliferation Arrested cell cycle Decreased tumor growth Suppressed migration, invasion, cancer stem cells and epithelial-mesenchymal transition	Decreased the protein level of Wnt5-α/β, increased the levels of NKD2 and Axin2, down-regulated β-catenin	[91]
DHA	Suppressed proliferation Induced apoptosis Inhibited angiogenesis	Influenced the expression of VEGF receptor KDR/flk-1, enhanced the effects of chemotherapeutics	[92]
DHA	Induced apoptosis	Increased the concentration of Ca²⁺, activated p38	[93]