Table 5.

Anti-brain glioma cells activities of artemisinins

Compounds	Effect	Event/mechanism	References
DHA	Inhibited proliferation	Induced autophagy	[34]
AS	Induce oxidative DNA damage	Resulted in DNA double-strand breaks (DSB) with phosphorylation of ATM, ATR, Chk1, and Chk2	[100]
DHA	Inhibited proliferation Induced apoptosis Induced cell cycle arrest	Increased Cleaved Caspase-3, decreased the expression of p-AKT, down-regulated AKT phosphorylation followed by Caspase-3 activation	[101]
ATM	Inhibited the migration and invasion Promoted the apoptosis	Inhibited the expression of MMP-2/9 and p-AKT	[102]
DHA	Inhibited proliferation Inhibited migration and invasion	Suppressed the expressions of a disintegrin and metalloproteinase 17 (ADAM17), and phosphorylated epidermal growth factor receptor and AKT (p-EGFR and p-AKT, respectively)	[103]