Table 5.
Compounds | Effect | Event/mechanism | References |
---|---|---|---|
DHA | Inhibited proliferation | Induced autophagy | [34] |
AS | Induce oxidative DNA damage | Resulted in DNA double-strand breaks (DSB) with phosphorylation of ATM, ATR, Chk1, and Chk2 | [100] |
DHA | Inhibited proliferation Induced apoptosis Induced cell cycle arrest |
Increased Cleaved Caspase-3, decreased the expression of p-AKT, down-regulated AKT phosphorylation followed by Caspase-3 activation | [101] |
ATM | Inhibited the migration and invasion Promoted the apoptosis |
Inhibited the expression of MMP-2/9 and p-AKT | [102] |
DHA | Inhibited proliferation Inhibited migration and invasion |
Suppressed the expressions of a disintegrin and metalloproteinase 17 (ADAM17), and phosphorylated epidermal growth factor receptor and AKT (p-EGFR and p-AKT, respectively) | [103] |