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. 2018 Aug 20;9:3334. doi: 10.1038/s41467-018-05798-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Multi-enzyme activity of MnO₂@PtCo nanoflowers in normoxia. a The study of PtCo nanozymes’ oxidase-like activity. Time-dependent absorbance changes at 652 nm of TMB in the presence of PtCo at N₂ gas (mimicking hypoxic condition) or not. b Oxygen generation in H₂O₂ solution with MnO₂ added under different pH values (7.4 and 5.0). c The study of MnO₂ component’s CAT-like activity. UV–vis spectra of remain H₂O₂ were recorded after reacting with different nanomaterials. d The study of MnO₂@PtCo nanoflowers’ oxidase-like activity. Time-dependent absorbance changes at 652 nm of TMB with different treatments. e The qualitative analysis of different nanomaterials’ oxidase activity. 1: control; 2: MnO₂; 3: PtCo; 4: MnO₂@PtCo; 5: PtCo in N₂ gas; 6: MnO₂@PtCo in N₂ gas. Data were presented as mean ± s.d. (n = 5)