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. 2018 Aug 20;9:3334. doi: 10.1038/s41467-018-05798-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — The pharmacokinetics studies of MnO₂@PtCo nanoflowers. a The biodistribution of nanoflowers in main organs and tumors at different time points. b The blood circulation curve of intravenously injected nanoflowers. c The eliminating rate curve of nanoflowers from the blood circulation curve according to the In(concentration)–T relationship. d The apparent volume percentage of distribution (V_d%) of intravenously injected nanoflowers. Data were presented as mean ± s.d. (n = 3)