Figure 2.

TDZ protects against model septic injury. (A) Survival curve of mice (n = 14, each group) treated with LPS alone (20 mg/kg, i.p.) or in combination with TDZ (15 mg/kg, i.p.) 1 h prior to LPS. (B) Lung histological analyses were performed using hematoxylin and eosin (H&E) staining in control and TDZ pre-treated mice 8 h after LPS challenge. Representative images from three mice per phenotype analyzed in three independent experiments are shown. Scale bar = 100 µm. Significance was determined using Fisher’s exact test. ^**P < 0.001.