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. 2018 Aug 20;8:12420. doi: 10.1038/s41598-018-30436-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Detection of Parkinson’s disease (PD)-specific pathological changes in a mutant Guangxi Bama minipig. (A–C) One 3-month-old mutant Guangxi Bama minipig (1–2#) was used to detect PD-specific pathological changes in the substantia nigra by α-synuclein immunohistochemical staining. (D–F) One age-matched wild-type (WT) minipig (1–4#) was used as a negative control. (B,C,E,F) Higher-magnification images show no classical α-synuclein-immunopositive pathology in the substantia nigra of the mutant minipig at 3 months of age (B,C) compared to the age-matched WT minipig (E,F). Note that the immunohistochemistry was performed on the brain tissue from the same two minipigs that were euthanized for mRNA analysis.