Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 20;8:12420. doi: 10.1038/s41598-018-30436-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Detection of dopaminergic neuron loss in the substantia nigra of a mutant Guangxi Bama minipig. (A–D) A mutant Guangxi Bama minipig (1–2#; A and C) and a wild-type (WT) control (#1–4; B and D) at 3 months of age were used for tyrosine hydroxylase (TH) immunohistochemical staining of the dopaminergic neurons in the substantia nigra. At least three randomly selected sections from approximately the same anatomic parts of mesencephalon were examined. (E) The number of dopaminergic neurons (No. of TH-positive cells) are expressed as the mean ± standard deviation (SD), and differences between the two minipigs were analyzed by two-tailed Student’s t-test. The statistical analysis showed that there was no significant difference between the mutant minipig and WT control at 3 months of age. Note that the immunohistochemistry was performed on the brain tissue from the same two minipigs that were euthanized for mRNA analysis. (SN, substantia nigra; VTA, ventral tegmental area).

HHS Vulnerability Disclosure