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. 2018 Aug 20;3:23. doi: 10.1038/s41525-018-0063-6

Table 2.

IFN-γ inducible genes upregulated >1.5-fold following IFN-γ stimulation in U3A cells

Variant Gene
WT CXCL10a, GBP2a, GBP1a, GBP4a, GBP5a, TAP1a, PARP9a, NMIa, DTX3La, HLA-Ea, PSMB9a, GBP3, IRF1, SP110, APOL6, AIM2, C1R, HAPLN3, LRRTM2, UBA7, TRIM69, IRF9
H629Y CXCL10a, GBP2a, GBP1a, GBP4a, GBP5a, TAP1a, PARP9a, NMIa, DTX3La, HLA-Ea, PSMB9a, CXCL9, WARS, SERPING1, UBE2L6, TRIM21, TLR2b, IFI44Lb, APOL3b, TINAGL1b, FZD10b, OARD1b, KLC2b, TRAV8-4b
R274G CXCL10a, GBP2a, GBP1a, GBP4a, GBP5a, TAP1a, PARP9a, NMIa, DTX3La, HLA-Ea, PSMB9a, CXCL9, WARS, SERPING1, UBE2L6, TRIM21, GBP3, IRF1, SP110, APOL6, AIM2, C1R, HAPLN3, LRRTM2, UBA7, TRIM69, IRF9, CXCL11c, UBDc, IDO1c, TNFSF10c, PARP14c, SAMD9Lc, IL18BPc, ICAM1c, RTP4c, IFIT3c, CD74c, XAF1c, IFI30c, RSAD2c, STAT2c,TRIM22c, PRRT2c, CTSSc, PSMB8c, OAS2c, C1Sc, CIITAc, PARP12c, PSMB10c, PDCD1LG2c, SLAMF8c, ACSL5c, IFIH1c, FLT3LGc, HLA-DRAc, IL32c, C4Bc, GCH1c, SOCS1c, C4c, HLA-DOBc, MMP8c, TAP2c, HLA-Ac, SPTLC3c, IFI35c, DDX58c, CD274c, TLR3c, IFIT2c, NREPc, NLRC5c, TAPBPLc, ERAP2c, RGCCc, ZC3HAV1c, BCL6c, XRN1c, HELZ2c, IRF2c, PMLc

WT wild type

aGene expression commonly upregulated in WT, H629Y and R274G

bGene expression unique to H629Y

cGene expression unique to R274G