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. 2018 Aug 20;8:12434. doi: 10.1038/s41598-018-30603-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Co-expression of Mcl-1 reduces apoptosis induction by Bax and BaxΔTM but has no impact on Bax(L63E) and Bax(L63E)ΔTM induced apoptosis in HCT116/WT and HCT116/DKO cells. (B) Loss of ΔΨm due to expression of Bax and BaxΔTM is reduced by co-expression of Mcl-1 but unchanged in case of Bax(L63E) and Bax(L63E)ΔTM. (C) Bak induced apoptosis is reduced by co-expression of Mcl-1 in HCT116/WT and HCT116/DKO whereas BakΔTM induced apoptosis is only reduced by Mcl-1 in HCT116/WT but not in HCT116/DKO. Bak(L78E) and Bak(L78E)ΔTM only marginally induce apoptosis that is not influenced by Mcl-1 co-expression. (D) Bak and BakΔTM induced dissipation of the mitochondrial membrane potential is reduced by Mcl-1 in HCT116/WT. In HCT116/DKO Bak induced loss of the mitochondrial membrane potential is reduced by Mcl-1 expression. (E) In HCT116/WT cells Mcl-1 expression has no significant impact on apoptosis induction by Bok, BokΔTM, Bok(L70E) and Bok(L70E)ΔTM. In the absence of endogenous Bax&Bak co-expression of Mcl-1 reduces apoptosis induction by Bok and Bok(L70E) whereas BokΔTM and Bok(L70E)ΔTM induced apoptosis is not influenced by Mcl-1 in HCT116/DKO. (F) Dissipation of the mitochondrial membrane potential in Bok, Bok(L70E) and Bok(L70E)ΔTM expressing HCT116/WT cells is reduced by Mcl-1 co-expression. In the absence of Bax&Bak dissipation of the mitochondrial membrane potential is reduced by Mcl-1 in Bok and Bok(L70E) expressing cells whereas BokΔTM and Bok(L70E)ΔTM induced loss of the mitochondrial membrane potential is not affected by Mcl-1 expression.