Figure 2.

Age-normalized immune reconstitution (IR) in the first year after haplo-stem cell transplantation (SCT) IR normalized by age-specific norm values (27) Table S1 in Supplementary Material, of (A) leukocytes, (B) lymphocytes, (C) monocytes, (D) T cells, (E) helper T cells, (F) cytotoxic T cells, (G) natural killer, and (H) B cells in the first year after transplantation. The curves illustrate the splines of the longitudinal trajectory of IR after SCT based on our joint models with point wise 95% confidence regions. The CR-MAC and CR-RIC panels (left and right panel, respectively) exhibit the predicted IR for patients in any remission prior to SCT according to the type of graft PBSC_CD34sel (solid line with dark gray confidence regions) or PBSC_CD3/CD19dep (dashed line with light gray confidence regions). (I) CD4/CD8 ratio of the absolute cell count of CD4⁺ helper T cells and CD8⁺ cytotoxic T cells at different time points after SCT. See also Figure S1 in Supplementary Material for a representation of absolute numbers for predicted values for a 10-year-old child. ns, not significant; *P < 0.05; **P < 0.01; ***P < 0.001.