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. 2018 Aug 14;9:1905. doi: 10.3389/fimmu.2018.01905

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Copyright © 2018 Kwon, Lim, Jang, Lee, Park, Kim, Yun, Shin, Jo, Oh, Roh and Choi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Oral administration of Lactobacillus sakei WIKIM30 ameliorates atopic dermatitis (AD)-like symptoms. (A) Experimental design. To induce AD-like immunologic features and skin lesions in mice, DNCB was applied to the dorsal skin. Phosphate-buffered saline (PBS), ketotifen, or L. sakei WIKIM30 was orally administered once daily for 6 weeks. (B) AD-like skin lesions were evaluated by visual observation. (C,D) Serum immunoglobulin (Ig)E and interleukin (IL)-4 levels were detected by sandwich enzyme-linked immunosorbent assay. (E,F) Dorsal skin sections were stained with hematoxylin and eosin or Toluidine Blue. Skin thickness and cell infiltration (E) and mast cell number and degranulation (F) were evaluated by histological analysis. Data represent the mean ± SE of n = 5 mice per group in three independent experiments. Student’s t-test (unpaired); *p < 0.05, **p < 0.01 vs. AD group.