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. 2018 Aug 14;9:1905. doi: 10.3389/fimmu.2018.01905

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Copyright © 2018 Kwon, Lim, Jang, Lee, Park, Kim, Yun, Shin, Jo, Oh, Roh and Choi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of WIKIM30 on alpha and beta diversity. Alpha and beta diversity of gut microbiota in normal mice and in atopic dermatitis (AD) mice without or with WIKIM30 treatment was evaluated. (A) Richness of gut microbiota is indicated by the Chao1 index; diversity is indicated by the Shannon and Simpson indices. Student’s t-test (unpaired); *p < 0.05, **p < 0.01, ***p < 0.001 vs. AD group. (B) Beta diversity pattern determined by principal coordinate analysis. Naïve, normal mice (blue); AD, DNCB-induced AD mice (red); W30, DNCB-induced AD mice with oral administration of WIKIM30 (green).