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. 2018 Aug 14;8:311. doi: 10.3389/fonc.2018.00311

Table 1.

Lung cancer classification.

Location in the lung Common features Common mutations
NSCLC (80–85%) Adenocarcinoma (40%) Peripheral

  • Most common type of cancer in non- smokers

  • More common in women

  • Should test for EGFR, ALK, ROS1 and BRAF mutation for targeted therapy

  • EGFR

  • KRAS

  • CDKN2A

  • ALK

  • BRAF

  • MET

  • TP53
Squamous cell carcinoma (25-30%) Central and Peripheral

  • Strongly associated with cigarette smoking
Large cell carcinoma (10-15%) Peripheral

  • Similar characteristics to adenocarcinoma
SCLC (15–20%) Central

  • Strongest association with smoking

  • Very rapid growth

  • Early distant metastasis in brain, liver and bone

  • Worst prognosis

  • Better response to chemotherapy

  • MYC

  • BCL2

  • c-KIT

  • TP53

  • RB