Table 1.

Lung cancer classification.

		Location in the lung	Common features	Common mutations
NSCLC (80–85%)	Adenocarcinoma (40%)	Peripheral	Most common type of cancer in non- smokers More common in women Should test for EGFR, ALK, ROS1 and BRAF mutation for targeted therapy	EGFR KRAS CDKN2A ALK BRAF MET TP53
	Squamous cell carcinoma (25-30%)	Central and Peripheral	Strongly associated with cigarette smoking
	Large cell carcinoma (10-15%)	Peripheral	Similar characteristics to adenocarcinoma
SCLC (15–20%)		Central	Strongest association with smoking Very rapid growth Early distant metastasis in brain, liver and bone Worst prognosis Better response to chemotherapy	MYC BCL2 c-KIT TP53 RB