Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Apr 25;23(5):1004. doi: 10.3390/molecules23051004

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Metabolic pathway and metabolic kinetic constant information of imperatorin and isoimperatorin in human liver microsomes. (A) 50 µM Imperatorin (or isoimperatorin) was incubated with recombinant CYP450s, and the relative quantity of metabolite M1, M2, M3 and M4 were determined by the peak area of extract ion chromatograms. (B,C) Summary of imperatorin and isoimperatorin metabolic pathways. (D,E) Imperatorin (or isoimperatorin) metabolites formation rate vs. its parent drug Log concentrations (in accordance with the Michaelis–Menten saturation curve) and their K_m and V_max in human liver microsomes were calculated from the Eadie–Hofstee plot (inset).