Table 1.
The effects of total coumarin extract (TCE) and ligustrazine on the frequency of head scratching in rats with migrine (n = 6).
| Group | Dose (mg/kg) | Time after Injection of Nitroglycerin | |||
|---|---|---|---|---|---|
| 0–30 min | 30–60 min | 60–120 min | 120–180 min | ||
| Control | 0.80 ± 0.34 | 1.21 ± 0.67 | 0.92 ± 0.45 | 1.01 ± 0.42 | |
| Model (nitroglycerin) | 10 | 43.07 ± 5.87 ## | 47.90 ± 3.87 ## | 73.96 ± 3.24 ## | 51.61 ± 2.80 ## |
| Sumatriptan | 0.005 | 39.17 ± 3.92 | 41.02 ± 5.67 | 45.30 ± 4.57 ** | 23.57 ± 4.43 ** |
| TCE | 50 | 46.06 ± 8.23 | 46.78 ± 4.45 | 53.24 ± 4.06 ** | 47.93 ± 4.26 |
| Ligustrazine | 15 | 42.90 ± 8.70 | 45 36 ± 2.45 | 50.50 ± 5.47 ** | 38.40 ± 2.95 ** |
| TCE + ligustrazine | 50 + 15 | 38.20 ± 4.43 | 44.81 ± 3.72 | 40.20 ± 4.48 **& | 28.20 ± 3.05 **&& |
Mean ± standard deviation (SD) ## p < 0.01, compared with control group; ** p < 0.01 compared with model group; & p < 0.05, && p < 0.01 compared with Ligustrazine group. TCE: total coumarin extract of A. dahuricae.