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. 2018 Apr 25;23(5):1004. doi: 10.3390/molecules23051004

Table 3.

IC50 of imperatorin and isoimperatorin on CYP450s (n = 3).

CYP450
Isoform		 IC50 (µM)
(95% Confidence Interval)
Imperatorin Isoimperatorin Positive Control a
CYP1A2 0.08
(0.052–0.13)		 8.26
(5.75–11.88)		 0.09
(0.06–0.12)
CYP2C9 4.81
(3.05–7.71)		 5.69
(3.21–10.09)		 0.14
(0.10–0.18)
CYP2C19 83.34
(0.66–104.85)		 19.58
(12.72–30.15)		 6.00
(2.76–13.00)
CYP2D6 9.10
(5.328–15.56)		 1.56
(0.54–4.5)		 0.05
(0.02–0.11)
CYP3A4 1.10
(0.71–1.71)		 1.47
(0.99–2.17)		 1.38
(0.74–2.56)

a Selective inhibitors for CYP450: α-naphthoflavone for CYP1A2, sulfaphenazole for CYP2C9, quinidine for CYP2D6, troglitazone for CYP2C19, and ketoconazole for CYP3A4.