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. 2018 Apr 29;23(5):1043. doi: 10.3390/molecules23051043

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme 1 — Synthesis of the target compounds 5a–h. Reagents and conditions: (i) Methanol, drops of H₂SO₄, reflux, 4 h; (ii) Methanol, H₂N-NH₂.H₂O, reflux, 2 h; and (iii) Acetonitrile, reflux 2 h.