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. 2018 May 4;23(5):1083. doi: 10.3390/molecules23051083

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Apoptosis induced by compound 7 in MCF-7 cells. (A) Apoptosis quantification, using Annexin V/PI double staining assay after treatment with compound 7 for 48 h. MCF-7 cells were harvested and stained with PI and Annexin V-FITC in darkness for 15 min, followed by flow cytometry analysis. Lower right: Annexin V+/PI− (early apoptosis); upper right: Annexin V+/PI+ (late apoptosis and necrosis). (B) The expression of Bcl-2, Bcl-XL and Bax was assessed through western blotting analyses of MCF-7 (treated for 48 h with varying concentrations of the compound), β-actin was used as internal control.