Table 1.
Cytotoxicity parameters of some naturally occurring coumarins and O-naphthoquinones against different solid tumor cell lines.
| Compound | HCT-116 | HepG2 | MCF-7 | HeLa | ||||
|---|---|---|---|---|---|---|---|---|
| IC50 (µM) | R-Fraction (%) | IC50 (µM) | R-Fraction (%) | IC50 (µM) | R-Fraction (%) | IC50 (µM) | R-Fraction (%) | |
| Mansorin-A (1) | 11.2 | 0.0 | 3.9 | 46.5 | 2.1 | 90.5 | 12.3 | 1.5 |
| Mansorin-B (2) | 5.7 | 26.3 | 21.9 | 0.0 | 5.0 | 78.9 | 38.7 | 1.3 |
| Mansorin-C (3) | 8.6 | 49.9 | 12.1 | 31.3 | 3.1 | 77.2 | 1.0 | 3.5 |
| Mansorin-I (4) | 11.1 | 0.0 | 35.3 | 0.0 | 23.8 | 0.0 | 3.95 | 0.0 |
| Mansorin-II (7) | 19.3 | 0.36 | 26.8 | 0.0 | 36.0 | 0.0 | 0.74 | 5.7 |
| Mansorin III (8) | >100 | 0.0 | 7.2 | 69.6 | >100 | 0.0 | 5.2 | 39.8 |
| Mansonone-G (5) | 63.4 | 0.5 | 49.4 | 1.1 | 23.0 | 5.1 | 18.8 | 1.8 |
| Mansonone-N (6) | >100 | 0.0 | >100 | 5.2 | >100 | 97.2 | >100 | 0.0 |