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Effect of mansorin-II on the cytotoxicity parameters of PTX in colorectal cancer cell lines.
| HCT-116 | CaCo-2 | |||
|---|---|---|---|---|
| IC50 | R-Value (%) | IC50 | R-Value (%) | |
| PTX | 27.9 ± 10.2 nM | 14.2 ± 5.3 | 2.1 ± 0.8 µM | 3.1 ± 0.37 |
| Mansorin-II | 19.3 ± 3.7 µM | 0.36 ± 0.007 | 107.9 ± 6.4 µM | 0.34 ± 0.004 |
| PTX with mansorin-II | 5.1 ± 1.9 nM | 11.6 ± 6.3 | 0.13 ± 0.03 µM | 1.8 ± 0.25 |
| CI-index/CI-value | Synergism/0.44 | Synergism/0.18 | ||
