Table I.
Effect of fermented Cordyceps sinensis on mortality and cardiac weight indexes in doxorubicin-treated rats.
| Groups | No. of rats pre-treatment | No. of treatment induced mortalities | No. of surviving rats post-treatment | Mortality (%) | BW (g) | LVWI (mg/g) | HWI (mg/g) |
|---|---|---|---|---|---|---|---|
| Normal control | 10 | 0 | 10 | 0 | 286.2±6.93 | 2.22±0.05 | 2.79±0.05 |
| DOX control | 15 | 6 | 9 | 40.00a | 208.3±12.50b | 2.50±0.09b | 3.11±0.10b |
| DOX plus captopril | 13 | 3 | 10 | 23.08 | 224.8±8.25 | 2.18±0.05d | 2.73±0.06d |
| DOX plus 0.75 g/kg CS | 13 | 5 | 8 | 38.46 | 216.3±6.36 | 2.33±0.07 | 2.90±0.08 |
| DOX plus 1.50 g/kg CS | 14 | 0 | 14 | 0c | 211.0±7.64 | 2.40±0.05 | 3.00±0.08 |
| DOX plus 3.00 g/kg CS | 14 | 2 | 12 | 14.29 | 219.0±7.53 | 2.26±0.06d | 2.85±0.08c |
| CS control | 5 | 0 | 5 | 0 | 292.0±11.14 | 2.21±0.04 | 2.76±0.05 |
Rats were treated with DOX alone or in combination with 0.05 g/kg captopril, or with 0.75, 1.5 or 3 g/kg CS. The number of rats assigned to each group prior to treatment, and the number that survived and succumbed to treatment are presented as well as the percentage of mortality. BW, LVWI and HWI were also measured. Data are presented as the mean ± standard error mean.
a
P<0.05
b
P<0.01 vs. the normal control group
c
P<0.05
d
P<0.01 vs. the DOX control group. BW, body weight; LVWI, left ventricular weight index; HWI, heart weight index; CS, Cordyceps sinensis; DOX, doxorubicin.