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. Author manuscript; available in PMC: 2018 Aug 21.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2017 Jun 23;52(5):503–542. doi: 10.1080/10409238.2017.1337705

Figure 7.

Figure 7

X-ray structure alignment of Gram-negative Family 2 LTs, displaying conservation of the 3D domain (Pfam: PF06725). The 3D domain is comprised of two subdomains linked by a hinge. The two structures show an open (E. coli MltA) and a closed (N. gonorrhoeae LtgC) protein conformation. The structure overlay aligns the top sub-domain. The bottom sub-domains are also conserved, but align differently in the open and closed states. The ribbon representation of each apo LT crystal structure is displayed to the right with a transparent surface representation. A color version of this figure is available at www.tandfonline.com/ibmg.