Figure 3.

Combinations of peptide A3-APO and colistin or imipenem in a bacteremia mouse model with Klebsiella pneumoniae infection with survival (A) and blood bacterial counts (B) outcomes. Treatment was administered at 1, 12, and 24 h after infection as described in Materials and Methods. Imipenem (30 mg/kg) and colistin (10 mg/kg) were administered subcutaneously. Peptide A3-APO was added intramuscularly at doses 1 or 0.5 mg/kg. Survival was monitored continuously after infection. The (A) figures in parenthesis represent the number of surviving animals after 36 h (out of 5). The open symbols in (B) represent CFU/mL counts from the blood of individual mice, and the filled magenta circle is a mean of the individual mouse data. The assay detection limit is 10³ CFU/mL; all results under this value are displayed as 100.