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. 2018 Aug 14;6:309. doi: 10.3389/fchem.2018.00309

Table 2.

Treatment success in mice infected with Burkholderia pseudomallei 1026b.

Antibiotic Dose (mg/kg)—administration route Number of deaths Median survival (days post-challenge) B. pseudomallei load in survivals (CFU/spleen)—(total number of samples analyzed/samples with CFU > 108)
Untreated Saline - sc 10 4 No survival
Ceftazidime 300 - ip 3 Undefined (>50% survival) 2.4 × 105−(3/1)
Ceftazidime 150 - ip 6 56.5 2.6 × 105−(4/1)
ARV-1502 5 - im 10 4 No survival
Ceftazidime + ARV-1502 150 ip + 2.5 im 4 Undefined (>50% survival) 3.1 × 106−(6/1)
Ceftazidime + ARV-1502 150 ip + 5 im 6 56.5 8.6 x 106−(4/0)
Ceftazidime + ARV-1502 150 ip + 10 im 7 50 7.6 x 106−(3/0)

The antibiotics were administered for 21 days, every 6 h, beginning 24 h post-challenge. After completion of the assay at day 62, surviving animals were euthanized and their spleens removed for bacterial count determination. The values in the last column are the mean of samples with < 108 CFU/spleen.