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. 2018 Aug 21;19:148. doi: 10.1186/s12881-018-0580-2

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Pathogenic mutations in the DSG2 protein and structure of KCNE5 mutations. a secondary structure of DSG2 protein (NP_001934.2), which consists of 1118 amino acids. The pathogenic mutation related to ARVC/D, hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) were displayed according to PubMed ClinVar and recent reports from PubMed. b-d primary (b) and tertiary (c–d) structure changes of KCNE5 p.D92E/E93X mutation and wildtype of KCNE5, constructed by Swiss-model. *, stop-gain