Table 5.
Predicted target genes in representative set of enriched gene ontology biological process terms
| Enriched Term | Gene Ontology Id | Target Genes (within all 16 miRNAs) | Targets in 3 miRNA Subset |
|---|---|---|---|
| G1/S transition of mitotic cell cycle | GO:0000082 | CCNE2, ACVR1B, EIF4E, CACUL1, CAMK2G, CAMK2D, USP37, RANBP1, RPS6KB1, PPP3CA, PHF8, LATS2, RBBP8 | 19a: CACUL1, RBBP81 181a: RPS6KB1 |
| regulation of establishment of cell polarity | GO:2000114 | ROCK1, GATA3, KRIT1, RICTOR, ARFGEF1, KANK1 | 19a: ARFGEF1 181: KANK1 |
| negative regulation of apoptotic process | GO:0043066 | FKBP8, TAF9B, NAA15, FOXO1, TP63, CITED2, SETX, PTK2, CASP3, DAB2, PRKAA1, RARB, HSPA5, AGO4, DNAJC3, KLHL20, CDK1, PDCD10, ADAMTS20, ZNF830, CBL, ASIC2, IGF1, RHBDD1, UBE2B, ASCL1, HSP90B1, GSK3B, HIPK3, VEGFA, ARF4, MAPK8, MDM4, APBB2, CAMK1D | 19a: HIPK3a, MDM4, MAPK8, ADAMTS20, KLHL20 181a: HIPK3a, HSP90B1, UBE2B, TAF9B, DNAJC3 |
| establishment of cell polarity | GO:0030010 | RAB11FIP2, UST, RICTOR, WEE1, EPHB1, MARK1, KIF26B | 19a: WEE1 181a: RAB11FIP2, MARK1 |
| intrinsic apoptotic signaling pathway by p53 class mediator | GO:0072332 | ZMAT1, ZMAT4, ZMAT3, PPP1R13B, ZNF385B, DDX5, ZNF346 | 19a: ZNF385B |
| negative regulation of extrinsic apoptotic signaling pathway | GO:2001237 | PHIP, ZMYND11, NRP1, ITGA6, IGF1, PSME3, RPS6KB1, SGMS1, GCLM | 19a: ZMYND11 181a: GCLM, RPS6KB1 |
| histone ubiquitination | GO:0016574 | SUZ12, UBE2A, HUWE1, UBE2B, PHC1 | 19a: UBE2A, SUZ12 181a: UBE2B |
| neuronal stem cell population maintenance | GO:0097150 | NOTCH1, FOXO1, DLL1, FOXO3, CDH2, PROX1, MMP24 | 181a: PROX1 |
| chromatin remodeling | GO:0006338 | ATRX, TOP1, RSF1, HNF1A, GATA3, MORF4L2, INO80, CHD1, TP63, ARID1B, SMARCA2, RERE | 19a: INO80a, SMARCA2, ATRX 181a: INO80a |
| positive regulation of cell-substrate adhesion | GO:0010811 | PPM1F, SMOC2, CCDC80, JAK2, NID1, EDIL3, PRKCE, ABI3BP | 19a: SMOC2 181a: ABI3BP |
| histone H3-K9 trimethylation | GO:0036124 | BEND3, ARID4A, ARID4B | |
| histone H2A ubiquitination | GO:0033522 | UBE2A, UBR2, UBE2B | 19a: UBE2A 181a: UBE2B |
| positive regulation of cell proliferation | GO:0008284 | KMT2D, CNBP, CACUL1, ESM1, IL34, CNOT7, CNOT6, TGFB2, PTK2, S1PR1, KRAS, CNOT6L, RARB, LOC488215, INSR, ACER3, UBE2A, PDCD10, KLB, SLC25A5, MECP2, ROGDI, IGF1, DLL1, TET1, SUZ12, ADM, HIPK1, HDAC1, VEGFA, HBEGF, MAB21L1, CARM1, EIF5A2 | 18a: KLB 19a: S1PR1a, CNOT7, CACUL1, NOT6, UBE2A, ROGDI, HIPK1, SUZ12 181a: S1PR1a, ESM1, CARM1, ADM |
| negative regulation of cell migration | GO:0030336 | PTPRJ, RAP2A, ADARB1, RAP2C, OSBPL8, ABHD2, KANK1, THY1, SFRP1, ROBO1, RRAS, TP53INP1, SRGAP2 | 19a: RAP2C 181a: KANK1, OSBPL8, ADARB1 |
| histone H3-K4 trimethylation | GO:0080182 | TET3, BEND3, ARID4A, KMT2A, CTR9 | 181a: KMT2A |
| stem cell population maintenance | GO:0019827 | PHF19, EIF4E, NIPBL, MED28, MTF2, EOMES, KLF4, DDX6, CTR9 | 18a: PHF19 19a: DDX6 |
| cell migration | GO:0016477 | CCDC88A, AVL9, CDH2, VAV2, EPHB3, SDC4, TGFB2, SDC1, SORBS2, GSK3B, ARF4, CDC42BPA, JAK2, LIMD1, LAMC1, CSK, KCTD13, NFATC2, USP33 | 18a: SDC4, SORBS2 19a: USP33a, NFATC2, CCDC88A, SDC1, EPHB3 181a: USP33a, AVL9, CDC42BPA |
Gene symbols with superscripted letter (a) in last column denote gene targets associated with more than one miRNA