Table 2.

Results in the development index of the MP-R Scale at week 8 (primary endpoint) and specific domains of the MP-R Scale

Age equivalents (months)		PLACEBO (Group A)(N = 11)	MINOCYCLINE Group B)(N = 21)	Absolute mean differences,95% CI
Primary analysis: Absolute mean changes in the DI (age equivalent in months) of the MP-R Scale
Development index	Baseline	12·55 (6·53)	12·00 (6·27)	0·545, 95% CI (−4·29–5·38)
	Week 8	14·55 (4·90)	13·90 (6·06)	0·641, 95% CI (−3·69–4·97)
	Absolute mean change	2·00 (3·28)	1·90 (3·16)	0·095, 95% CI (−2·22–2·53)
Secondary analysis: Specific domains of the MP-R scale
Cognition	Baseline	11·55 (6·18)	12·76 (6·89)	−1·216, 95% CI (−6·28–3·85)
	Week 8	15·09 (5·46)	14·24 (5·89)	0·852, 95% CI (−3·50–5·22)
	Absolute mean change	3·54 (4·4)	1·47 (2·22)	2·069, 95% CI (−0·31–4·44)
Fine Motor	Baseline	12·18 (5·94)	11·67 (5·78)	0·515, 95% CI (−3·92–4·95)
	Week 8	14·82 (4·30)	13·71 (5·77)	1·104, 95% CI (−2·94–5·15)
	Absolute mean change	2·63 (4·17)	2·04 (3·93)	0·588, 95% CI (−2·46–3·64)
Visual Motor Coordination	Baseline	12·09 (6·42)	11·29 (6·95)	0·805, 95% CI (−4·34–5·95)
	Week 8	15·55 (4·59)	16·24 (7·48)	- 0·693, 95% CI (−5·75–4·37)
	Absolute mean change	3·45 (4·54)	4·95 (6·31)	−1·497, 95% CI (− 5·89–2·89)
Gross Motor Scale	Baseline	20·64 (7·90)	18·81 (6·83)	1·827, 95% CI (−3·65–7·30)
	Week 8	20·64 (5·87)	20·05 (7·50)	0·589, 95% CI (−4·73–5·91)
	Absolute mean change	0·00 (7·16)	1·23 (3·20)	−1·238, 95% CI (−4·96–2·48)
Socio-emotional	Baseline	19·09 (13·59)	18·57 (7·99)	0·519, 95% CI (−7·24–8·27)
	Week 8	15·82 (7·54)	17·62 (8·26)	-1·801, 95% CI (−7·90–4·30)
	Absolute mean change	−3·27 (7·48)	−0·95 (7·04)	−2·320, 95% CI (− 7·98–3·14)
Adaptive Behavior Scale and Self Care	Baseline	20·73 (8·69)	20·29 (6·55)	0·442, 95% CI (−5·13–6·01)
	Week 8	21·73 (9·64)	21·24 (7·06)	0·489, 95% CI (−5·60–6·58)
	Absolute mean change	1·00 (4·66)	0·95 (3·42)	0·047, 95% CI (−2·90–3·00)