Table 4.
Absolute mean changes in the development index of the MP-R scale at week 24
| Age equivalents (months) | Group A (Placebo-Minocycline) (N = 11) | Group B1 (Minocycline-Placebo) (N = 11) | Group B2 (Minocycline- Minocycline) (N = 10) | p value | |
|---|---|---|---|---|---|
| Primary endpoint: Absolute mean changes in the DI (age equivalent in months) of the MP-R Scale | |||||
| Development index | Baseline | 12·55 (6·53) | 13·09 (6·31) | 10·80 (6·33) | 0·699 |
| Week 24 | 14·80 (6·17) | 13·00 (7·89) | 7·80 (5·63) | 0·689 | |
| Absolute mean change | 1·30 (4·32) | −0·09 (3·93) | −3·00 (5·90) | 0·139 | |
| Secondary analysis: Development index after 8-week wash-out period | |||||
| Development index | Absolute mean change | −0·80 (3·39) | −1·00 (3·94) | −4·20 (8·79) | 0·365 |
| Age equivalents (months) | After 8 weeks from the suspension of Minocycline (N = 21) | After 16 weeks from the suspension of Minocycline (N = 11) | Absolute mean differences, 95% CI, p value | ||
| Development index | Absolute mean change | −0·94 (3·67) | −2·27 (4·12) | −1·32· 95% CI (− 1·65–4·30) | |