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Function of the main proteins involved in the purinergic pathway. ABCC6 transporter allows, in part, the release of ATP, which is metabolized by some ecto-nucleotidases (such as ENPP1) in AMP, in adenosine by CD73 and Pi by TNAP. ABCC6, ATP-binding cassette, sub-family C, member 6; ENPP1, ecto-nucleotide pyrophosphatase/phosphodiesterase type I; CD73, cluster of differentiation 73; TNAP, tissue non-specific alkaline phosphatase; Pi, inorganic phosphate; PPi, inorganic pyrophosphate.
