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. 2018 Aug 14;11:259. doi: 10.3389/fnmol.2018.00259

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Copyright © 2018 Barry, Sondermann, Sondermann, Gomez-Varela and Schmidt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Region-resolved changes in the FSTL1-NKA-protein network upon SNI. Differential regulation of mean protein abundance across SN, DRG, and SC becomes apparent and is visualized by a graded color code. Node color code: red, upregulated; green, downregulated; gray, unchanged; white, not detected. Moreover, causal network analysis predicts differences in activation (line color orange) and inhibition (line color blue) of distinct connections between members of this network. Predicted relationship among nodes is indicated by dashed lines. All graphs are created by IPA®. Up-and downregulation refer to proteins that were significantly regulated across all three replicates (Benjamini-Hochberg-corrected p-value, q < 0.05) upon SNI.