Table 1.
List of putative PNS-enriched candidate proteins in humans.
| Entry | Protein names | Gene names |
|---|---|---|
| Q9WV68 | Peroxisomal 2,4-dienoyl-CoA reductase (EC 1.3.1.34) (2,4-dienoyl-CoA reductase 2) | Decr2 Pdcr |
| Q9WUP4 | Polyprenol reductase (EC 1.3.1.94) (3-oxo-5-alpha-steroid 4-dehydrogenase 3) (EC 1.3.1.22) (Steroid 5-alpha-reductase 2-like) (Steroid 5-alpha-reductase 3) (S5AR 3) (SR type 3) | Srd5a3 Srd5a2l |
| Q9WU66* | Secreted frizzled-related protein 5 (sFRP-5) | Sfrp5 |
| Q9R059 | Four and a half LIM domains protein 3 (FHL-3) (Skeletal muscle LIM-protein 2) (SLIM-2) | Fhl3 |
| Q9R053* | Sodium channel protein type 11 subunit alpha (NaN) (Sensory neuron sodium channel 2) (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) | Scn11a Nan Nat Sns2 |
| Q9QZZ6 | Dermatopontin (Early quiescence protein 1) (EQ-1) (Tyrosine-rich acidic matrix protein) (TRAMP) | Dpt |
| Q9QYY0 | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Gab1 |
| Q9JLK7 | Calcium-binding protein 1 (CaBP1) | Cabp1 |
| Q9JLB2 | MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1) | Mpp5 Pals1 |
| Q9JKJ9 | 24-hydroxycholesterol 7-alpha-hydroxylase (EC 1.14.14.26) (Cytochrome P450 39A1) (mCYP39A1) (Oxysterol 7-alpha-hydroxylase) | Cyp39a1 |
| Q9JJH1 | Ribonuclease 4 (RNase 4) (EC 3.1.27.-) | Rnase4 |
| Q9ET38* | Claudin-19 (CLDN19) | Cldn19 |
| Q9ESB3 | Histidine-rich glycoprotein (Histidine-proline-rich glycoprotein) (HPRG) | Hrg |
| Q9ERA0 | Alpha-globin transcription factor CP2 | Tfcp2 Tcfcp2 |
| Q9ER60 | Sodium channel protein type 4 subunit alpha (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) | Scn4a |
| Q9EPX2 | Papilin | Papln |
| Q9EPV8 | Ubiquitin-like protein 5 | Ubl5 |
| Q9EPL9 | Peroxisomal acyl-coenzyme A oxidase 3 (EC 1.3.3.6) (Branched-chain acyl-CoA oxidase) (BRCACox) (Pristanoyl-CoA oxidase) | Acox3 |
| Q9EPB5 | Serine hydrolase-like protein (SHL) (EC 3.1.-.-) | Serhl |
| Q9DBN5 | Lon protease homolog 2, peroxisomal (EC 3.4.21.-) (Lon protease-like protein 2) (Lon protease 2) (Peroxisomal Lon protease) | Lonp2 |
| Q9DBG7 | Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) | Srpra Srpr |
| Q9DBD0 | Inhibitor of carbonic anhydrase | Ica |
| Q9DB16 | Calcium-binding protein 39-like (MO25beta) (Mo25-like protein) | Cab39l |
| Q9D2R4 | Transmembrane emp24 domain-containing protein 11 (Glycoprotein 25L) (GP25L) (p24 family protein alpha-1) (p24alpha1) | Tmed11 |
| Q9D281 | Protein Noxp20 (Nervous system overexpressed protein 20) (Protein FAM114A1) | Fam114a1 Noxp20 |
| Q9CXX9 | CUE domain-containing protein 2 | Cuedc2 |
| Q9CWP6 | Motile sperm domain-containing protein 2 | Mospd2 |
| Q9CWG8 | Protein arginine methyltransferase NDUFAF7, mitochondrial (EC 2.1.1.320) (NADH dehydrogenase [ubiquinone] complex I, assembly factor 7) (Protein midA homolog) | Ndufaf7 |
| Q9CQW9 | Interferon-induced transmembrane protein 3 (Dispanin subfamily A member 2b) (DSPA2b) (Fragilis protein) (Interferon-inducible protein 15) (Mouse ifitm-like protein 1) (Mil-1) | Ifitm3 |
| Q9CQ20 | Mid1-interacting protein 1 (Gastrulation-specific G12-like protein) (Mid1-interacting G12-like protein) (Protein STRAIT11499 homolog) (Spot 14-related protein) (S14R) (Spot 14-R) | Mid1ip1 Mig12 |
| Q99PM3 | Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)] | Gtf2a1 |
| Q99M08 | Uncharacterized protein C4orf3 homolog | NA |
| Q99LJ6 | Glutathione peroxidase 7 (GPx-7) (GSHPx-7) (EC 1.11.1.9) | Gpx7 |
| Q99JS0* | Noncompact myelin-associated protein (Myelin protein of 11 kDa) (MP11) | Ncmap |
| Q99JF5 | Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase) | Mvd |
| Q99JA0* | Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I) | Calca Calc |
| Q923B6 | Metalloreductase STEAP4 (EC 1.16.1.-) (Dudulin-4) (Six-transmembrane epithelial antigen of prostate 4) (Tumor necrosis factor-alpha-induced adipose-related protein) | Steap4 Tiarp |
| Q921L5 | Conserved oligomeric Golgi complex subunit 2 (COG complex subunit 2) (Component of oligomeric Golgi complex 2) (Low density lipoprotein receptor defect C-complementing protein) | Cog2 Ldlc |
| Q91YI4 | Beta-arrestin-2 (Arrestin beta-2) | Arrb2 |
| Q91WP6 | Serine protease inhibitor A3N (Serpin A3N) | Serpina3n Spi2 |
| Q91W59 | RNA-binding motif, single-stranded-interacting protein 1 (Single-stranded DNA-binding protein MSSP-1) | Rbms1 Mssp Mssp1 |
| Q91V01 | Lysophospholipid acyltransferase 5 (LPLAT 5) (EC 2.3.1.-) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) | Lpcat3 Grcc3f Mboat5 Oact5 |
| Q8VE11 | Myotubularin-related protein 6 (EC 3.1.3.-) | Mtmr6 |
| Q8VC98* | Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1) | Plekha4 Pepp1 |
| Q8R3U1 | HRAS-like suppressor 3 (HRSL3) (EC 3.1.1.32) (EC 3.1.1.4) (Adipose-specific phospholipase A2) (AdPLA) (Group XVI phospholipase A2) (H-rev 107 protein homolog) | Pla2g16 H-rev107 Hrasls3 Hrev107 |
| Q8R3I3 | Conserved oligomeric Golgi complex subunit 6 (COG complex subunit 6) (Component of oligomeric Golgi complex 6) | Cog6 Kiaa1134 |
| Q8R3I2 | Lysophospholipid acyltransferase 2 (LPLAT 2) (EC 2.3.1.-) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) | Mboat2 Lpcat4 Oact2 |
| Q8R189 | Monocyte to macrophage differentiation factor 2 (Progestin and adipoQ receptor family member X) | Mmd2 Paqr10 |
| Q8R100 | Protein FAM26E | Fam26e |
| Q8K4K6 | Pantothenate kinase 1 (mPank) (mPank1) (EC 2.7.1.33) (Pantothenic acid kinase 1) | Pank1 Pank |
| Q8K2V1 | Serine/threonine-protein phosphatase 4 regulatory subunit 1 | Ppp4r1 |
| Q8K296 | Myotubularin-related protein 3 (EC 3.1.3.48) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) | Mtmr3 |
| Q8K1B8 | Fermitin family homolog 3 (Kindlin-3) (Unc-112-related protein 2) | Fermt3 Kind3 Urp2 |
| Q8CI59 | Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Protein nm1054) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) | Steap3 Tsap6 |
| Q8CG14 | Complement C1s-A subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s-A) [Cleaved into: Complement C1s-A subcomponent heavy chain; Complement C1s-A subcomponent light chain] | C1sa C1s |
| Q8CD91 | SPARC-related modular calcium-binding protein 2 (Secreted modular calcium-binding protein 2) (SMOC-2) | Smoc2 |
| Q8C650 | Septin-10 | Sept10 |
| Q8C008 | Double zinc ribbon and ankyrin repeat-containing protein 1 | Dzank1 |
| Q8BWL5 | RNA-binding motif, single-stranded-interacting protein 3 | Rbms3 |
| Q8BS95 | Golgi pH regulator (Protein GPR89) | Gpr89a Gphr Gpr89 |
| Q8BRH3 | Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19) | Arhgap19 |
| Q8BND5 | Sulfhydryl oxidase 1 (mSOx) (EC 1.8.3.2) (Quiescin Q6) (Skin sulfhydryl oxidase) | Qsox1 Qscn6 Sox |
| Q8BMB3 | Eukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (eIF4E-2) (mRNA cap-binding protein type 2) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP) | Eif4e2 Eif4el3 |
| Q8BH97 | Reticulocalbin-3 | Rcn3 D7Ertd671e |
| Q8BGD6 | Sodium-coupled neutral amino acid transporter 9 (Solute carrier family 38 member 9) | Slc38a9 |
| Q8BFY0* | Phosphoinositide-interacting protein | Pirt |
| Q80X19 | Collagen alpha-1(XIV) chain (COEA1) | Col14a1 |
| Q80WG7* | E3 ubiquitin-protein ligase Trim36 (EC 2.3.2.27) (Acrosome RBCC protein) (Haprin) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) | Trim36 |
| Q80VM7 | Ankyrin repeat domain-containing protein 24 | Ankrd24 |
| Q7TQ62 | Podocan | Podn |
| Q704Y3* | Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) | Trpv1 |
| Q6QIY3* | Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (Sensory neuron sodium channel) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) | Scn10a Sns |
| Q6PFX8 | N-acetylaspartylglutamate synthase A (NAAG synthetase A) (NAAGS) (EC 6.3.2.41) (N-acetylaspartylglutamylglutamate synthase A) (EC 6.3.2.42) (Ribosomal protein S6 modification-like protein A) | Rimkla Fam80a Rimk |
| Q6NZK8 | Protein tyrosine phosphatase domain-containing protein 1 (EC 3.1.3.-) | Ptpdc1 |
| Q6A009 | E3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING finger protein 160) (RING-type E3 ubiquitin transferase listerin) (Zinc finger protein 294) (Zfp-294) | Ltn1 Kiaa0714 Lister Rnf160 Zfp294 Znf294 |
| Q62147 | Sarcospan (K-ras oncogene-associated protein) (Kirsten-Ras-associated protein) | Sspn Krag |
| Q61245 | Collagen alpha-1(XI) chain (COBA1) | Col11a1 |
| Q60632 | COUP transcription factor 1 (COUP-TF1) (COUP transcription factor I) (COUP-TF I) (Nuclear receptor subfamily 2 group F member 1) (V-erbA-related protein 3) (EAR-3) | Nr2f1 Erbal3 Tfcoup1 |
| Q5FW60 | Major urinary protein 20 (Darcin) (Major urinary protein 24) | Mup20 Mup24 |
| Q3V4B5 | COMM domain-containing protein 6 | Commd6 |
| Q3V3R4 | Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a) | Itga1 |
| Q3UZV7 | UPF0577 protein KIAA1324-like homolog (Estrogen-induced gene 121-like protein) (EIG121L) | NA |
| Q3UR32* | P2X purinoceptor 3 (P2X3) (ATP receptor) (Purinergic receptor) | P2rx3 |
| Q3UPR9 | Somatomedin-B and thrombospondin type-1 domain-containing protein (RPE-spondin) | Sbspon Gm106 Rpesp |
| Q3TZX8 | Polynucleotide 5′-hydroxyl-kinase NOL9 (EC 2.7.1.-) (Nucleolar protein 9) | Nol9 |
| Q01339 | Beta-2-glycoprotein 1 (APC inhibitor) (Activated protein C-binding protein) (Apolipoprotein H) (Apo-H) (Beta-2-glycoprotein I) (B2GPI) (Beta(2)GPI) | Apoh B2gp1 |
| P82347 | Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG) | Sgcd |
| P70271 | PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein) | Pdlim4 Ril |
| P70160* | Calcitonin | Calca Calc |
| P70158 | Acid sphingomyelinase-like phosphodiesterase 3a (ASM-like phosphodiesterase 3a) (EC 3.1.4.-) | Smpdl3a Asml3a |
| P57724 | Poly(rC)-binding protein 4 (Alpha-CP4) | Pcbp4 |
| P51885 | Lumican (Keratan sulfate proteoglycan lumican) (KSPG lumican) | Lum Lcn Ldc |
| P51642* | Ciliary neurotrophic factor (CNTF) | Cntf |
| P50608 | Fibromodulin (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin) | Fmod |
| P50285 | Dimethylaniline monooxygenase [N-oxide-forming] 1 (EC 1.14.13.8) (Dimethylaniline oxidase 1) (Hepatic flavin-containing monooxygenase 1) (FMO 1) | Fmo1 Fmo-1 |
| P48410 | ATP-binding cassette sub-family D member 1 (Adrenoleukodystrophy protein) (ALDP) | Abcd1 Ald Aldgh |
| P47880 | Insulin-like growth factor-binding protein 6 (IBP-6) (IGF-binding protein 6) (IGFBP-6) | Igfbp6 Igfbp-6 |
| P46412 | Glutathione peroxidase 3 (GPx-3) (GSHPx-3) (EC 1.11.1.9) (Plasma glutathione peroxidase) (GPx-P) (GSHPx-P) | Gpx3 |
| P43135 | COUP transcription factor 2 (COUP-TF2) (Apolipoprotein AI regulatory protein 1) (ARP-1) (COUP transcription factor II) (COUP-TF II) (Nuclear receptor subfamily 2 group F member 2) | Nr2f2 Aporp1 Arp-1 Arp1 Tfcoup2 |
| P42925 | Peroxisomal membrane protein 2 (22 kDa peroxisomal membrane protein) | Pxmp2 Pmp22 |
| P40936 | Indolethylamine N-methyltransferase (Indolamine N-methyltransferase) (EC 2.1.1.49) (EC 2.1.1.96) (Aromatic alkylamine N-methyltransferase) (Amine N-methyltransferase) (Arylamine N-methyltransferase) (Thioether S-methyltransferase) (TEMT) | Inmt Temt |
| P33622 | Apolipoprotein C-III (Apo-CIII) (ApoC-III) (Apolipoprotein C3) | Apoc3 |
| P24526 | Myelin P2 protein (MYP2) | Pmp2 |
| P21812 | Mast cell protease 4 (mMCP-4) (EC 3.4.21.-) (MSMCP) (Myonase) (Serosal mast cell protease) | Mcpt4 |
| P19258 | Protein Mpv17 (Mpv-17) | Mpv17 |
| P14483 | H-2 class II histocompatibility antigen, A beta chain | H2-Ab1 H2-iabeta |
| P11589 | Major urinary protein 2 (MUP 2) | Mup2 |
| P08121 | Collagen alpha-1(III) chain (CO3A1) | Col3a1 |
| P08074 | Carbonyl reductase [NADPH] 2 (EC 1.1.1.184) (Adipocyte protein P27) (AP27) (Lung carbonyl reductase) (LCR) (NADPH-dependent carbonyl reductase 2) | Cbr2 |
| P06909 | Complement factor H (Protein beta-1-H) | Cfh Hf1 |
| P06684 | Complement C5 (Hemolytic complement) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain] | C5 Hc |
| P06330 | Ig heavy chain V region AC38 205.12 | NA |
| P04938 | Major urinary protein 11 | Mup11 Mup9 |
| P03987 | Ig gamma-3 chain C region | NA |
| P03975 | IgE-binding protein | Iap |
| P03953 | Complement factor D (EC 3.4.21.46) (28 kDa adipocyte protein) (Adipsin) (C3 convertase activator) (Properdin factor D) | Cfd Adn Df |
| P02762 | Major urinary protein 6 (MUP 6) (Alpha-2U-globulin) (Group 1, BS6) (allergen Mus m 1) | Mup6 |
| P01872 | Ig mu chain C region | Ighm Igh-6 |
| P01869 | Ig gamma-1 chain C region, membrane-bound form | Ighg1 Igh-4 |
| P01868 | Ig gamma-1 chain C region secreted form | Ighg1 Igh-4 |
| P01864 | Ig gamma-2A chain C region secreted form (B allele) | NA |
| P01843 | Ig lambda-1 chain C region | NA |
| P01837 | Ig kappa chain C region | Igkc |
| O89013 | Leptin receptor gene-related protein (Endospanin-1) (OB-R gene-related protein) (OB-RGRP) | Leprot Lepr Obr |
| O88630 | Golgi SNAP receptor complex member 1 (28 kDa Golgi SNARE protein) (28 kDa cis-Golgi SNARE p28) (GOS-28) | Gosr1 Gs28 |
| O88327 | Alpha-catulin (Alpha-catenin-related protein) (ACRP) (Catenin alpha-like protein 1) | Ctnnal1 Catnal1 |
| O70258 | Epsilon-sarcoglycan (Epsilon-SG) | Sgce |
| O35744 | Chitinase-like protein 3 (EC 3.2.1.52) (Beta-N-acetylhexosaminidase Ym1) (Chitinase-3-like protein 3) (ECF-L) (Eosinophil chemotactic cytokine) (Secreted protein Ym1) | Chil3 Chi3l3 Ym1 |
| B1AVZ0 | Uracil phosphoribosyltransferase homolog | Uprt |
| B1AS29 | Glutamate receptor ionotropic, kainate 3 (GluK3) (Glutamate receptor 7) (GluR-7) (GluR7) | Grik3 Glur7 |
| A2BIM8 | Major urinary protein 18 | Mup18 Mup16 |
| Q9JK53 | Prolargin (Proline-arginine-rich end leucine-rich repeat protein) | Prelp |
| Q9D4V3 | Coiled-coil domain-containing protein 83 | Ccdc83 |
| Q91XI1 | tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (EC 1.3.1.-) (tRNA-dihydrouridine synthase 3-like) | Dus3l |
| P60060 | Protein transport protein Sec61 subunit gamma | Sec61g |
| P27573* | Myelin protein P0 (MYP0) (Myelin peripheral protein) (MPP) (Myelin protein zero) | Mpz P0 |
| P21183 | Interleukin-5 receptor subunit alpha (IL-5 receptor subunit alpha) (IL-5R subunit alpha) (IL-5R-alpha) (IL-5RA) (CD antigen CD125) | Il5ra Il5r |
| Q8R502 | Volume-regulated anion channel subunit LRRC8C (Factor for adipocyte differentiation 158) (Leucine-rich repeat-containing protein 8C) | Lrrc8c Ad158 Fad158 |
| P11087 | Collagen alpha-1(I) chain (Alpha-1 type I collagen) (CO1A1) | Col1a1 Cola1 |
| P10493 | Nidogen-1 (NID-1) (Entactin) | Nid1 Ent |
| P07758 | Alpha-1-antitrypsin 1-1 (AAT) (Alpha-1 protease inhibitor 1) (Alpha-1-antiproteinase) (Serine protease inhibitor 1-1) (Serine protease inhibitor A1a) (Serpin A1a) | Serpina1a Dom1 Spi1-1 |
| Q3TGW2 | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | Eepd1 Kiaa1706 |
Comparison of our PNS-enriched proteome with the content of the Human Protein Atlas (Uhlen et al., 2015; Thul et al., 2017). Non-matching proteins are listed. Given the previously shown good agreement between sensory neurons in mice and humans, these listed proteins are putatively enriched in the human PNS. Moreover, proteins reported by Ray and colleagues (Ray et al., 2018) to be DRG-enriched and conserved in humans are labeled with *.