Assessed behaviors included a) open arm entries and b) time spent in the open arms. Clodronate treated males and clodronate treated females spent more time in the open arms than vehicle treated males and vehicle treated females (b), and entered the open arms more often (a). **p < 0.01, ***p < 0.001 n = 8 for clodronate treated males, n = 9 for vehicle treated males, n = 10 clodronate treated females, and n = 11 for vehicle treated females.