Fig. 6.
Comparison of the target site search time τ of the gene as function of the unspecific dissociation rate constant µ1 between a promoter activated by a single TF (TF, red line), a promoter activated by a dimer (Dimer µ = 10−3 s−1, solid blue line), activated by a dimer with lower specific dissociation rate constant (Dimer µ = 10−4 s−1, dashed blue line) and when an inhibitory competitor of the TF is present (Competitor, yellow line). In addition, the TF target site search time calculated from a model explicitly accounting for 1D diffusion is indicated (Diffusion model, dashed black line). Simulation parameters are: N = 100, C = 100, B = 104, λ10 = Λ10 = 4·10−4 s−1, λ0 = Λ0 = 10−5 s−1, λ2 = Λ2 = 4 s−1, ζ1 = 1 s−1, ζ = 10−3 s−1. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)