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. Author manuscript; available in PMC: 2018 Aug 21.
Published in final edited form as: Nat Genet. 2013 Sep 1;45(10):1190–1197. doi: 10.1038/ng.2743

Figure 1.

Figure 1

Frequencies of spontaneous resistance to ethambutol. Triplicate cultures of wild-type strain 210 and triplicate cultures of spontaneously ethambutol-resistant 210 mutants that had previously been selected with the indicated concentrations of ethambutol were replated on medium with ethambutol at the indicated concentrations. The mean frequency of colony-forming units (CFUs) recovered with each ethambutol concentration compared to in the no-drug control is shown. The number in each EMB ID indicates the ethambutol concentration (in µg/ml) under which in vitro strains were preselected. Error bars, s.d. of three independent experiments. *P < 0.05; significant differences compared to the 210 strain were determined by Student’s t test.